Drug Combo a Promising Treatment

​By Natalie van Hoose​ - Published May 18, 2015

ptenResearcher Xiaoqi Liu has discovered a drug combo that can potentially prolong lives of those with advanced prostate cancer. (Photo by Tom Campbell)

Low doses of metformin, a widely used diabetes medication, and a gene inhibitor known as BI2536 can successfully halt the growth of late-stage prostate cancer tumors, a Purdue University study finds.

Prostate cancer causes the second-highest number of cancer-related deaths in men in the U.S., and methods of treating advanced prostate cancer are limited.

Xiaoqi Liu, associate professor of biochemistry and cancer research, and fellow researchers have discovered a promising way to treat late-stage prostate cancer. "Combining low levels of two well-tolerated drugs could significantly delay the progression of this disease," Liu said. "Completely curing the cancer at the advanced stage is pretty much impossible, but this treatment might manage it for a while—that's exciting."

Liu and fellow researchers from Purdue collaborated with the University of Wisconsin-Madison and the Indiana University School of Medicine. The next step in the research is to test the combination of drugs in clinical trials.

Full Story

Drug combo suppresses growth of late-stage prostate cancer tumors

Related Link

Genes may be good target for tough-to-kill prostate cancer cells ​​

​​