Drug Combo a Promising Treatment
By Natalie van Hoose - Published May 18, 2015
Researcher Xiaoqi Liu has discovered a drug combo that can
potentially prolong lives of those with advanced prostate cancer. (Photo by Tom Campbell)
Low doses of metformin, a widely used diabetes medication, and a
gene inhibitor known as BI2536 can successfully halt the growth of late-stage
prostate cancer tumors, a Purdue University study finds.
Prostate cancer causes the second-highest number of
cancer-related deaths in men in the U.S., and methods of treating advanced
prostate cancer are limited.
Xiaoqi Liu, associate professor of biochemistry and cancer research, and fellow
researchers have discovered a promising way to treat late-stage prostate cancer.
"Combining low levels of two well-tolerated drugs could significantly delay the
progression of this disease," Liu said. "Completely curing the cancer at the
advanced stage is pretty much impossible, but this treatment might manage it
for a while—that's exciting."
Liu and fellow researchers from Purdue collaborated with the
University of Wisconsin-Madison and the Indiana University School of Medicine. The
next step in the research is to test the combination of drugs in clinical
Drug combo suppresses growth of late-stage prostate cancer tumors
Genes may be good target for tough-to-kill prostate cancer cells