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James F Markworth

Animal Sciences 

  • Assistant Professor
765.494.4846
765.494.9346
CRTN Room 2054
270 S. Russell St.
West Lafayette, IN 47907-2041

 General Information

Area of Expertise: Muscle Biology, Immunology, Molecular Nutrition

Education: Honors B.S., Deakin University, Melbourne, Australia; Ph.D., Deakin University, Melbourne, Australia.

Post-doctoral Training: University of Auckland, Auckland, New Zealand; University of Michigan, Ann Arbor, Michigan, USA.

Research Interests

My research group focuses broadly on the cellular and molecular mechanism of skeletal muscle plasticity with a particular focus on nutritional biochemistry and muscle-immune cell interactions. Current research topics include: (1) The role of endogenous metabolites of essential omega-3 (e.g. eicosapentaenoic acid [EPA]) and docosahexaenoic acid [DHA]) and -6 (e.g. arachidonic acid [ARA]) fatty acids known as bioactive lipid mediators the control of postnatal muscle cell growth (e.g. development, regeneration, hypertrophy). (2) The applicability of dietary intake of polyunsaturated fatty acids (PUFA) and downstream oxylipins (e.g. eicosanoids and docosanoids) as novel strategies to promote adaptive muscle growth and/or to ameliorate muscle wasting under conditions of chronic inflammatory stress (e.g. aging, metabolic disease, muscular dystrophies, cachexia, disuse). (3) The role of various resident and infiltrating blood immune cell populations (e.g. polymorphonuclear leukocytes, monocytes/macrophages, lymphocytes) in controlling muscular remodeling via cross-talk with resident muscle cells (myofibers and satellite cells).

Full list of publications: Google Scholar or ResearchGate

Interested in joining us? Please contact me at: jmarkwor@purdue.edu. The Graduate program requirements are: click here

 

Department of Animal Sciences, 270 S Russell Street, West Lafayette, IN 47907 USA, (765) 494-4808

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