Scott Mills

 

Scott Mills' Main Page

Research Program

Monogastric Nutrition/Growth Biology

Our interest is on the cellular signals regulating the growth of adipose and muscle tissue for the purpose of identifying tools to modify body composition for productive purposes. We also have interest in fat and meat quality with the goal of improving product quality in lean pigs. Much of our work has focused on how endocrine signals may be modified between adipose and muscle tissue to partition nutrients toward muscle growth and away from adipose growth. In recent years, we have embarked upon cloning the family of porcine beta-adrenergic receptors in order to dissect the mechanisms responsible for growth modification and to develop pig-specific agonist.

Research Techniques

  • Cell isolation and culture
  • In vitro and in vivo nutrient metabolism
  • Hormone receptor analysis
  • RNA quantification
  • DNA analysis and cell transfection

Selected Publications

Liu, C.Y., A.L. Grant, K.H. Kim and S.E. Mills. 1994. Porcine somatotropin decreases acetyl-CoA carboxylase gene expression in porcine adipose tissue. Dom. Anim. Endo. 11:125-132.

Wilson, L.A., S.E. Mills, E. Finley, E. Kilgour, P.J. Buttery and R.G. Vernon. 1997. Effect of lactation on insulin signal transduction in sheep adipose tissue and skeletal muscle. J. Endocrinology.

Liang, W., C.A. Bidwell, S.K. Williams and S.E. Mills. 1997. Rapid Communication: Molecular Cloning of the Porcine b2-Adrenergic Receptor Gene. J. Anim. Sci. 75:2824.

Cao, H., C.A. Bidwell, S.K. Williams, W. Liang and S.E. Mills. 1998. Nucleotide sequence of the coding region for the porcine b1-adrenergic receptor gene. J. Anim. Sci. (in press).

Taylor-Roth, J.L., P.V. Malven, D.E. Gerrard, S.E. Mills and A.L. Grant. 1998. Independent effects of food intake and insulin status on insulin-like growth factor 1 in young pigs. Comp. Biochem and Biophys. (in press).

Recent Abstracts

Mills, S.E. 1994. Evidence for functional segregation of beta-adrenergic receptors in porcine adipocytes with the ß3-agonist BRL-37344. J. Anim. Sci. (Suppl 1) 77:810.

Mills, S.E. and M. E. Spurlock. 1995. Tissue and specie variation in the activation of adenylate cyclase by b-adrenergic agonists. J. Anim. Sci. (suppl 1) 73:145.

Williams, S.K., W. Liang, C.A. Bidwell and S.E. Mills. 1996. Molecular cloning of the porcine b1-adrenergic receptor. FASEB.

Liang, W., S.K. Williams, C.A. Bidwell and S.E. Mills. 1996. Molecular cloning of the porcine beta 2-adrenergic receptor. J. Anim. Sci (suppl 1)

Cao, H., C.A. Bidwell and S.E. Mills. 1997. Expression of the porcine b1-adrenergic receptor in Chinese hamster ovary cells. J. Anim. Sci. 75:169.

Liang, W., S.K. Williams, C.A. Bidwell and S.E. Mills. 1997. Expression of the porcine b2-adrenergic receptor in CHO cells. J. Anim. Sci. 75:169.

Eggert, J.M , S.E. Mills, A.P. Schinckel, J.C. Forrest, A.L. Grant, B.A. Watkins, and E.J. Farrand. 1997. Effects of genotype and dietary fat on pork quality and carcass composition. J. Anim. Sci. (midwest meeting).

Eggert, J.M , S.E. Mills, A.P. Schinckel, J.C. Forrest, A.L. Grant, B.A. Watkins, and E.J. Farrand. 1997. Effects of genotype, dietary fat and slaughter weight on pork quality and carcass composition. J. Anim. Sci. (midwest meeting).

Eggert, J.M., A.P. Schinckel, S.E. Mills, J.C. Forrest, D.E. Gerrard, E.J. Farrand, B.C. Bowker and E.J. Wynveen. 1998. Effects of sire line on pig growth and carcass composition. J. Anim. Sci. (submitted).

Mills, S.E. 1998. Signal cross-talk by adrenergic receptors. Links to the regulation of protein metabolism. J. Anim. Sci. (submitted).

Brandebourg, T.D., M.E. Spurlock and S.E. Mills. 1998. The role of C/EBPa in mediating the antilipogenic effects of pST in finishing pigs. J. Anim. Sci. (submitted).

Liang, W., H. Cao and S.E. Mills. 1998. Classification of agonists and antagonists for the cloned porcine b2-adrenergic receptor using ligand binding. J. Anim. Sci. (submitted).

Cao, H., W. Liang, C.A. Bidwell and S.E. Mills. 1998. Kinetic comparison of porcine b1- and b2-adrenergic receptor in CHO cells. J. Anim. Sci. (submitted).