Dr. Karen Plaut Lab
Mammary Gland Biology Lab
The overall objective of our lab is to understand how cells, growth factors, hormones, organ systems and the environment interact to regulate mammary development and lactation. Presently our research is focused in two main areas: understanding the role of epithelial and stromal interactions in mammary development and neoplasia; and understanding how changes in physiology and metabolism are coordinated across multiple tissues during the periparturient period to prepare for and maintain lactation.
Joining the Lab
Plaut, K., and T. Casey. 2012. Does the circadian system regulate lactation? Animal 6:3, pp. 394-402.
Casey T, Dover H, Liesman J, DeVries L, Kiupel M, Vandehaar M, Plaut K. 2011. Transcriptome analysis of epithelial and stromal contributions to mammogenesis in three week prepartum cows. PLoS One. 2011;6(7):e22541. Epub 2011 Jul 29. PMID: 21829467 [PubMed - indexed for MEDLINE]
Patel OV, Casey T, Dover H, Plaut K. 2010. Homeorhetic adaptation to lactation: comparative transcriptome analysis of mammary, liver, and adipose tissue during the transition from pregnancy to lactation in rats. Funct Integr Genomics. 2011 Mar;11(1):193-202. Epub 2010 Sep 18. PMID: 20852911 [PubMed - indexed for MEDLINE]
Casey T, Patel O, Dykema K, Dover H, Furge K, Plaut K. 2009. Molecular signatures reveal circadian clocks may orchestrate the homeorhetic response to lactation. PLoS One. 2009 Oct 9;4(10):e7395. PMID: 19816599 [PubMed - indexed for MEDLINE]
Patel OV, Zakrzewska E, Maple RL, Baer LA, Ronca AE, Wade CE, Plaut K. 2008. Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion. Eur J Appl Physiol. 2008 Nov;104(5):847-58. Epub 2008 Jul 30. PMID: 18665386 [PubMed - indexed for MEDLINE]
Casey T, Bond J, Tighe S, Hunter T, Lintault L, Patel O, Eneman J, Crocker A, White J, Tessitore J, Stanley M, Harlow S, Weaver D, Muss H, Plaut K. 2008. Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer. Breast Cancer Res Treat. 2009 Mar;114(1):47-62. Epub 2008 Mar 29. PMID: 18373191 [PubMed - indexed for MEDLINE]
Casey TM, Plaut K. 2007. The role of glucocorticoids in secretory activation and milk secretion, a historical perspective. J Mammary Gland Biol Neoplasia. 2007 Dec;12(4):293-304. Epub 2007 Nov 14. Review. PMID: 18000742 [PubMed - indexed for MEDLINE]
Casey TM, Eneman J, Crocker A, White J, Tessitore J, Stanley M, Harlow S, Bunn JY, Weaver D, Muss H, Plaut K. 2008. Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study. Breast Cancer Res Treat. 2008 Jul;110(1):39-49. Epub 2007 Aug 3. PMID: 17674196 [PubMed - indexed for MEDLINE]
Muss HB, Bunn JY, Crocker A, Plaut K, Koh J, Heintz N, Rincon M, Weaver DL, Tam D, Beatty B, Kaufman P, Donovan M, Verbel D, Weiss L. 2007. Cyclin D-1, interleukin-6, HER-2/neu, transforming growth factor receptor-II and prediction of relapse in women with early stage, hormone receptor-positive breast cancer treated with tamoxifen. Breast J. 2007 Jul-Aug;13(4):337-45. PMID: 17593037 [PubMed - indexed for MEDLINE]
Lintault LM, Zakrzewska EI, Maple RL, Baer LA, Casey TM, Ronca AE, Wade CE, Plaut K. 2007. In a hypergravity environment neonatal survival is adversely affected by alterations in dam tissue metabolism rather than reduced food intake. J Appl Physiol. 2007 Jun;102(6):2186-93. Epub 2007 Feb 22. PMID: 17317876 [PubMed - indexed for MEDLINE]
Barlow J, Yandell D, Weaver D, Casey T, Plaut K. 2003. Higher stromal expression of transforming growth factor-beta type II receptors is associated with poorer prognosis breast tumors. Breast Cancer Res Treat. 2003 May;79(2):149-59. PMID: 12825850 [PubMed - indexed for MEDLINE]