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Barbara L Golden


  • Professor of Biochemistry
BCHM Room 22

Agricultural Research at Purdue 

  • Interim Assistant Dean for Graduate Education and Faculty Development

College of Agriculture Administration 

  • Asst Dean Faculty Affairs/Prof Biochem

Selected Publications

Chen, J., Manuel, G., Chamberlain, R., Luptak, A., & Golden, B. L. (2016). Engineering a ribozyme with tRNA synthetase activity. Manuscript in preparation.

Mir, A., & Golden, B. L. (2015). Two active site divalent ions in the crystal structure of the hammerhead ribozyme bound to a transition state analog. Manuscript submitted for publication.

Mir, A., Chen, J., Robinson, K., Lendy, E., Goodman, J., Neau, D., & Golden, B. L. (2015). Two Divalent Metal Ions and Conformational Changes Play Roles in theHammerhead Ribozyme Cleavage Reaction. Biochemistry, 54(41), 6369-6381. doi:10.1021/acs.biochem.5b00824

DeRose, V. J., Plakos, K., Golden, B. L., White, J., Osborn, M., & Moghaddam, A. (2014). RNA Crosslinking and Click Chemistry with Platinum Compounds. BIOPHYSICAL JOURNAL, 106(2, 1), 494A-495A.

Golden, B., Hammes-Schiffer, S., Carey, P., & Bevilacqua, P. (2013). An integrated picture of HDV ribozyme catalysis. In Biophysics of RNA Folding (., 135-168). New York: Springer.

Golden, B. (2013). Catalysis by RNA, structure themes: group I introns. In Encyclopedia of Biological Chemistry 2nd Edition (3, 397-400). Waltham, MA: Academic Press.

Chen, J., Ganguly, A., Miswan, Z., Hammes-Schiffer, S., Bevilacqua, P., & Golden, B. (2013). Identification of the catalytic Mg2+ ion in the hepatitis delta virus ribozyme. Biochemistry, 52, 557-567. Retrieved from http://pubs.acs.org/doi/pdf/10.1021/bi3013092

Thaplyal, P., Ganguly, A., Golden, B., Hammes-Schiffer, S., & Bevilacqua, P. (2013). Thio effects and an unconventional metal ion rescue in the genomic hapatitis delta virus ribozyme. Biochemistry, 52, 6499-6514. Retrieved from http://pubs.acs.org/doi/abs/10.1021/bi4000673

Bevilacqua, P. C., Thaplyal, P., Carey, P. R., Gong, B., Golden, B. L., Chen, J., . . . Ganguly, A. (2013). Key roles for electrostatics in the mechanism of the HDV ribozyme. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 246.

Thaplyal, P., Ganguly, A., Golden, B. L., Hammes-Schiffer, S., & Bevilacqua, P. C. (2013). Thio Effects and an Unconventional Metal Ion Rescue in the GenomicHepatitis Delta Virus Ribozyme. BIOCHEMISTRY, 52(37), 6499-6514. doi:10.1021/bi4000673

Awards & Honors

(2014) Co-Organizer. 19th Annual Meeting of the RNA Society.

(2014) Member. NIH MSFB Study Section.

(2014) University Faculty Scholar. Purdue University.

(2013) Member. NIH MSFB Study Section.

(2012) Lead Organizer. FASEB Nucleic Acid Enzymes Conference.

(2012) Member. NIH MSFB Study Section.

(2011) Seed for Success Award. Purdue University.

(2000) PEW Scholar. The Pew Scholars Program in the Biomedical Sciences.

Agricultural Research and Graduate Education, 615 West State Street, West Lafayette, IN 47907 USA, (765) 494-8370

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