Hi – I am Hai‐Ning and I am from the mainland of China. I got my bachelor degree in Chemistry at Peking University and got my Ph.D degree in biochemistry and molecular biology in Institutes for Biological Sciences, Chinese Academy of Science of China. I joined in Dr. Briggs lab in Nov. 2006. My research focuses on studying the function of Set2, a histone H3 K36‐specific methyltransferase in budding yeast. The reason why I am interested in Set2 is that the human homolog of Set2, HYPB, or Set2‐like proteins, NSD1‐3, have been linked with multiple human diseases, like neurodegenerative disease, childhood developmental diseases and acute myeloid leukemia, as well as breast cancer, respectively. Using the budding yeast Saccharomyces cerevisiae as a model system, investigating yeast Set2 will help us understanding the potential pathological mechanism of Set2‐related diseases.
South P.F., Fingerman I.M., Mersman D.P., Du H.N., and Briggs S.D. (2010) A conserved interaction between the SDI domain of Bre2 and the Dpy‐30 Domain of Sdc1 is required for histone methylation and gene expression. J. Biol. Chem., 285: 595‐607.
Mersman, D. P., Du, H. N., Fingerman, I. M., South, P. F., and Briggs, S. D. (2009) Polyubiquitination of the demethylase JHD2 controls histone methylation and gene expression. Genes & Dev., 23: 951‐962.
Dhawan, R., Luo, H., Foerster, A. M., AbuQamar, S., Du, H. N., Briggs, S. D., Scheid, O. M., and Mengiste, T. (2009) Histone Monoubiquitination interacts with a subunit of the mediator complex and regulates defense against necrotrophic fungal Pathogens in Arabidopsis. Plant Cell, 21: 1000‐1019.
Du, H. N., Fingerman, I. M., and Briggs, S. D. (2008) Histone H3 K36 methylation is mediated by a trans‐histone methylation pathway involving an interaction between Set2 and histone H4. Genes & Dev., 15: 2768‐2798.
Fingerman, I. M., Du, H. N., and Briggs, S. D. (2008) Controlling histone methylation via trans‐histone pathways. Epigenetics, 3: 237‐242. (Review)