Research Assistant Scientist
My name is Hana Hall, and I have been an Associate Research Scientist in Vikki Weake’s lab since May 2013. I am originally from Slovakia where I received my M.Sc. in genetics and molecular biology. I received my Ph.D. in 2004 from Comenius University in Bratislava, Slovakia. I studied nucleotide excision repair in mammalian cells at the Department of Molecular Genetics, at Cancer Research Institute in Bratislava and Leiden University, The Netherlands. Nucleotide excision repair is one of the most versatile DNA repair mechanisms, which if incomplete, may lead to higher incidence of cancer and other human disease. In 1999, while being in graduate school, I received Fulbright fellowship and spent almost a year in the lab of Tom Kunkel at NIEHS, North Carolina.
We moved to Indiana in 2004 and I started as a Postdoctoral Research Assistant in Tony Hazbun’s lab in 2005. My work focused on studying the aurora kinase Ipl1 in yeast using functional genomics approach. Aurora kinases are members of the Chromosome Passenger Complex, which is important for regulating chromosome segregation and cell division. Over-expression or de-regulation of mitotic kinases is commonly observed in human cancers and therefore finding an inhibition pathway for kinase activity is a potential anti-cancer therapy. I used synthetic dosage lethality screen with over-expressed Ipl1 kinase to find genetic interacting proteins which could serve as possible therapeutic targets.
In 2009 I joined Mark Hall’s lab where I studied the yeast Saccharomyces cerevisiae anaphase promoting complex/cyclosome (APC/C) which is an ubiquitin ligase that regulates mitosis, mitotic exit events and maintains G1 phase. After four years in Mark’s lab and over ten years working with yeast, I switched to study gene regulation and epigenetics in Drosophila. I joined Vikki Weake’s lab in May 2013. My project is focused on studying aging in Drosophila photoreceptors by assessing the levels of gene transcription and epigenetic modifications in young versus old flies, characterizing the contribution of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex to aging and identification of non-histone targets of SAGA complex.
I have three kids, so most of my time outside of the lab is spent with them. If I have some free time, I enjoy reading, yard work, yoga and running.
- Martinez JS, Hall H, Bartolowits MD, Hall MC.: Acm1 contributes to nuclear positioning by inhibiting Cdh1-substrate interactions, Cell Cycle. 2012 Jan 15;11(2):384-394
- Bremmer SC, Hall H, Martinez JS, Eissler CL, Hinrichsen TH, Rossie S, Parker LL, Hall MC, Charbonneau H.: Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine, J Biol Chem. 2012 Jan 13;287(3):1662-1669
- J. Luo, X. Xu, H. Hall, E.M. Hyland, J.D. Boeke, T. Habzun, and M-H. Kuo: Histone H3 Exerts a Key Function in Mitotic Checkpoint Control, Mol Cell Biol Jan 2010, Vol 30, No2; p. 537-549
- Hall, H., Gursky, J., Nicodemou, A., Kimlickova, E., Rybanska, I., and Pirsel, M.: Characterization of ERCC3 mutations in the Chinese hamster ovary 27-1, UV24 and MMC-2 cell lines, Mut Res. 2006 January 29; 593(1-2): 177-8
- T. Xiao, H. Hall, K.O. Kizer, Z. Shibata, M.C. Hall, C.H. Borchers and B.D. Strahl: Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yest, Genes and Development 17: 654-663, 2003
- Fousteri M., van Hoffen A., Vargova H., Mullenders L.H.: Repair of DNA lesions in chromosomal DNA: Impact of chromatin structure and Cockayne syndrome proteins, DNA Repair (Amst.) 2005 Jul; 4(8):919-925
- K.O. Kizer, H.P. Phatnani, Y. Shibata, H. Hall, A.L.Greenleaf and B.D. Strahl: A novel domain in Set2 mediates interaction with RNA polymerase II and couples H3 K36 methylation with transcription elongation, Mol Cell Biol 2005 Apr; 25(8):3305-3316