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Howard Zalkin


 Howard Zalkin


Emeritus Professor of Biochemistry

Department: Biochemistry

Area of Expertise: Regulation of gene expression, enzyme structure-function-regulation in aromatic amino acid biosynthesis, purine biosynthesis and the glutamine amidotransferase enzyme family

Retired: 1999



Sinha, S., Rappu, P., Lange, S.C., Mäntsälä, P, Zalkin, H., and Smith, J. L. Crystal Structure of Bacillus subtilis YabJ, A Purine Regulatory Protein and Member of the Highly Conserved YjgF Family. Proc. Natl. Acad. Sci. USA 96, 13074 (1999).  
Bera, A. K., Chen, S., Smith, J. L., and Zalkin, H. Interdomain Signalling in Glutamine Phosphoribosylpyrophosphate Amidotransferase. J. Biol. Chem. 274, 36498 (1999).   
Chen, S., Burgner, J. W., Krahn, J. M., Smith, J. L., and Zalkin, H. Tryptophan Fluorescence Monitors Multiple Conformational Changes Required for Glutamine Phosphoribosylpyrophosphate Amidotransferase Interdomain Signalling and Catalysis. Biochemistry 38, 11659 (1999).   
Rappu, P., Shin, B.S., Zalkin, H., and Mäntsälä, P. A Role for a Highly Conserved Protein of Unknown Function in Regulation of Bacillus subtilis purA by the Purine Repressor. J. Bacteriol. 181, 3810 (1999).    
Li, S., Smith, J. L., and Zalkin, H. Mutational analysis of Bacillus subtilis Glutamine Phosphoribosylpyrophosphate Amidotransferase Propeptide Processing. J. Bacteriol. 181, 1403 (1999).   
Arvidson, D. N., Lu, F., Faber, C., Zalkin, H., and Brennan, R. G. The Structure of PurR Mutant L54M Shows an to DNA Kinking. Nature Structural Biol. 5, 436 (1998).   
Lu, F., Brennan, R. G., and Zalkin, H. Escherichia coli Purine Repressor: Key Residues for the Allosteric Transition between Active and Inactive Conformations and for Interdomain Signaling. Biochemistry 37, 15680 (1998).   
Lu, F., Schumacher, M. A, Arvidson, D. N., Haldimann, A. C., Wanner, B. L., Zalkin, H., and Brennan, R. G. Structure-Based Redesign of Corepressor Specificity of the Escherichia coli Purine Repressor by Substitution of Residue 190. Biochemistry 37, 971 (1998).   
Muchmore, C. R. A, Krahn, J. M., Kim, J. H., Zalkin, H., and Smith, J. L. Crystal Structure of Glutamine Phosphoribosylpyrophosphate Amidotransferase from Escherichia coli. Protein Science 7, 39 (1998).   

Zalkin, H., and Smith, J. L. Enzymes Utilizing Glutamine as an Amide Donor. Adv. Enzymol. and Related Areas Mol. Biol. 72, 87 (1998).