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Karl Brandt

 

 Karl G. Brandt

 



Professor of Biochemistry

Department: Biochemistry
E-mail: brandtk@purdue.edu

Area of Expertise: Enzyme kinetics and mechanism; bioethics; teaching

Retired: 2007 

After spending eighteen years in academic administration as associate dean and director of academic programs for Purdue’s School of Agriculture, I returned to the Department of Biochemistry full time as a faculty member in July 2002. Prior to moving into administration, I had an active research program and published in the area of the kinetics and mechanism of enzyme-catalyzed reactions. I employed both steady-state and stopped-flow kinetic methods, with a principal focus on flavin-mediated oxidation-reduction reactions. I also taught graduate-level courses in both areas. I retain an interest in these general areas and am interested in working in a consultative/advisory capacity with graduate students whose thesis projects involve any element of enzymology and/or kinetics.

My interest in bioethics has evolved from an avocational interest in philosophy and public policy dating back to my undergraduate days. I spent the spring 2003 semester on sabbatical leave at Duke University studying bioethics under Allen Buchanan, professor of philosophy and public policy, in the Sanford Institute of Public Policy, and in affiliation with Duke’s Center for Genome Ethics, Law and Policy headed by Robert Cook-Deegan. 

I am particularly interested in two broad areas.

  1. Does the developed world have a moral/ethical responsibility to address problems of the underdeveloped world that a) admit of a scientific solution and b) are potentially solvable if the developed world were to commit sufficient resources and make their solution a priority? If so, how can those arguments be crafted into effective public policy? Currently, I am focusing my study and writing in the area of parasitic diseases such as malaria. 
  2. The issue of therapeutic cloning (cloning-for-medical-research) has generated much debate. I am interested in this debate, particularly as such cloning is seen by many as offering potential treatments for a number of challenging, debilitating diseases. Among my interests is the exploration of whether it is possible to develop arguments that defend the use of therapeutic cloning as a viable approach to the solution of such problems, and how our views on the moral status of the human embryo, human dignity and beneficence affect our views on the ethics/morality of therapeutic cloning.

For the next few years, my energies will be focused heavily on undergraduate teaching. For many years, enhanced by my experiences as an administrator of academic programs, I have had an abiding interest in the areas of curriculum and of teaching excellence. They still occupy my thinking. Are we educating our students – undergraduate, graduate, post-graduate – well? What constitutes a good curriculum? How do you decide if a curriculum is good? What is the difference between “education” and “training”? How does one become an excellent teacher? What is teaching excellence? Can it be learned/taught, or is it innate? Can we enhance our teaching skills? How can we promote the practice of talking with our colleagues about our teaching with the same enthusiasm that we approach talking with our colleagues about our research?

 

 Publications

 

Journal Articles and Book Chapters

Sherban, D.G., Kennelly, P.J., Brandt, K.G., and Rodwell, V.W. Rat Liver HMG-CoA Reductase: Catalysis of the Reverse Reaction and Two Half-Reactions. J. Biol. Chem. 260, 12579-12585 (1985).


Huber, P.W., and Brandt, K.G. Kinetic Studies of the Reduction of Yeast Glutathione Reductase by Reduced Nicotinamide Hypoxanthine Dinucleotide Phosphate. Arch. Biochem. Biophys. 238, 213-218 (1985).


Harwood, H.J., Jr., Brandt, K.G., and Rodwell, V.W. Allosteric Activation of Rat Liver Cytosolic HMG-CoA Reductase Kinase by Nucleoside Diphosphates. J. Biol. Chem. 259, 2810-2815 (1984).


Kennelly, P.J., Brandt, K.G., and Rodwell, V.W. 3-Hydroxy-3-methylglutaryl-CoA Reductase: Solubilization in the Presence of Proteolytic Inhibitors, Partial Purification, and Reversible Phosphorylation-Dephosphorylation. Biochemistry 22, 2784-2788 (1983).

 

Huber, P.W., and Brandt, K.G. Kinetic Studies of Pyridine Nucleotide-Dependent Reduction of Yeast Glutathione Reductase. Biochemistry 19, 4568-4575 (1980).

 

Brandt, K.G., and Lutton, J.K. Kinetic Studies of the Effect of ADP-ribose on Pig Heart Lipoamide Dehydrogenase in Flavins and Flavoproteins (Singer, T.P., ed.), Elsevier, Amsterdam, 1976, pp. 478-484.

 

Moroff, G., Ochs, R.S., and Brandt, K.G. Yeast Glutathione Reductase. Steady-State Kinetic Studies of Its Transhydrogenase Activity. Arch. Biochem. Biophys. 173, 42-49 (1976).

 

Moroff, G., and Brandt, K.G. Yeast Glutathione Reductase. Studies of the Kinetics and Stability of the Enzyme as a Function of pH and Salt Concentration. Biochim. Biophys. Acta 410, 21-31 (1975).

 

Moroff, G., and Brandt, K.G. Steady-State Kinetic Investigation of Specific Anion Effects on the Catalytic Activity of Yeast Glutathione Reductase. Arch. Biochem. Biophys. 159, 468-474 (1973).

 

Rogers, M.J., and Brandt, K.G. Multiple Inhibition Analysis of A. niger Glucose Oxidase by D-Glucal and Halide Ions. Biochemistry 10, 4636-4641 (1971).

 

 

Symposium Papers

Brandt, K.G. Introduction and A Challenge, a Charge, and a Commitment, in Agriculture and the Undergraduate, Proceedings, Board on Agriculture, National Research Council, National Academy Press, Washington, D.C., 1992, pp. 24-26 and 121-122.  
Brandt, K.G. Funding Laboratories for Effective Instruction, in Strategies for Teaching and Learning, Proceedings of the North Central Teaching Symposium, June 24-26, 1991, University of Wisconsin, Madison, WI, F. H. Buelow (editor), The University of Wisconsin, pp. 19-22.  
Brandt, K.G. And Where in the World Will You Work? in National and International Aspirations and Priorities, Proceedings of the 1988 AASCARR Annual Meeting, October 1-4, 1988, River Falls, WI, pp. 25-30. Published by the American Association of State Colleges and Universities, One Dupont Circle/ Suite 700, Washington, DC, 1989.  
Brandt, K.G. Improving the International Content of our Teaching Programs and Curriculum, in Proceedings, Association of U.S. University Directors of International Agricultural Programs: Preparing for the Future, June 7-9, 1988, University of Arkansas, Fayetteville, AR, pp. 86-91, 1989.  
Brandt, K.G. Agricultural Curricula -- Some Provocative Questions, in Proceedings, National Curriculum Revitalization - 2005 Conference, St. Louis, MO, October 21-22, 1987, D. J. Mugler (ed.). Published by Kansas State University, Manhattan, KS, pp. 8-11, 1988.  
Brandt, K.G. The Impact of Biotechnology on Higher Education in Agriculture, Eighth Working Conference of Representatives of Higher Education in Agriculture, held under the auspices of the Directorate for Food, Agriculture and Fisheries, at the Organisation for Economic Co-operation and Development, Paris, France, November 23-27, 1987. p. 24.  
Brandt, K.G. International Agricultural Curricular Dimensions for the Future. Curricular Innovation for 2005, The North Central Curricular Committee Project, University of Wisconsin-Madison, Madison, WI, 1987, pp. 69-85. [Curricular Innovation for 2005 has been translated, in entirety, into Japanese and reissued in 1991 as part of the "Higher Education" series published by the research institute at Hiroshima University, Higashi-Hiroshima 721, Japan.]  

 

Abstracts

Lechtenberg, V.L., and Brandt, K.G. Agricultural Research - Recruiting Opportunities for High School Students. Agronomy Abstr., 3 (1987).  
Kennelly, P.J., Sherban, D.G., Brandt, K.G., and Rodwell, V.W. Characterization of Rat Liver 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase Solubilized in the Presence of Inhibitors of Proteolysis. J. Lipid Res. 24, 1408 (1983).  
Kennelly, P.J., Sherban, D.G., and Brandt, K.G. Characterization of Rat Liver 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Solubilized in the Presence of Inhibitors of Proteolysis. Federation Proc. 42, 1965 (1983).  
Huber, P.W., and Brandt, K.G. Mechanism of Pyridine Nucleotide-Dependent Reduction of Yeast Glutathione Reductase. Federation Proc. 37, 1606 (1978).  
Texter, F.L., Lutton, J.K., and Brandt, K.G. Steady-State Kinetic Studies of the Lipoamide Dehydrogenase Component within the Pig Heart Pyruvate Dehydrogenase Complex. Federation Proc. 36, 875 (1977).  
Brandt, K.G., and Pyne, J.W., Jr. Stopped-Flow Kinetic Evidence for a Catalytically-competent Ternary Complex in the Mechanism of Yeast Glutathione Reductase. Federation Proc. 35, 1705 (1976).  
Himoe, A., Brandt, K.G., Czerlinski, G., and Hess, G.P. Investigations of Individual Steps in the Chymotrypsin-catalyzed Hydrolysis of Specific Substrates by Flow and Relaxation Techniques. Federation Proc. 26, 447 (1967).  
Czerlinski, G., Brandt, K.G., Nelson, W.L., and Hess, G.P. Investigation of Cytochrome c Systems by Relaxation Techniques. Federation Proc. 24, 288 (1965).  

 

Invited Presentations

Brandt, K. G.  “To Educate, not to Train,” USA-Europe Workshop: Comparative Issues in the USA and Europe – Consequences for the Future of Agronomic Higher Education, Ecole Supérieure d’Agriculture – Purpan, Toulouse, France, July 2-4, 2001.
Brandt, K. G. “The Road We Choose to Take,” USA-Europe Workshop: Agricultural Status Trends in Modern Society: Comparative Issues in the USA and Europe – Consequences for the Future of Agronomic Higher Education, Ecole Supérieure d’Agriculture – Purpan, Toulouse, France, July 2-4, 2001.
Brandt, K. G. “Human Resources: Supply, Demand, and the Implications for Education,” Economics of Agriculture and the Food Industry, Workshop for Teachers, Grades 5-12, sponsored by the Indiana Council for Economic Education, Indiana University - Purdue University Indianapolis, July 26, 1996.
Brandt, K. G.  “Agricultural and Renewable Resources Curriculums for the Future,” Annual Meeting, American Association of State Colleges of Agriculture and Renewable Resources, Texas Tech University, Lubbock, TX, September 27, 1993.
Brandt, K. G.  “Yon Calculation has a Mean and Hungry Look,” Book review of Beyond Numeracy (John Allen Paulos, Alfred A. Knopf, 1991), North Central Deans and Directors Meeting, University of Nebraska, Lincoln, NE, March 30-April 1, 1992.
Brandt, K. G.  “What I Believe…And Why I Worry,” Investing in the Future: Professional Education for the Undergraduate, National Academy of Sciences, Washington, DC, April 15, 1991.
Brandt, K. G. “Master of the House,” International Symposium on Electronic Evaluation of Meat in Support of Value-Based Marketing, Purdue University, March 27, 1991.
Brandt, K. G. “Recruiting Agriculture Students in the 1990s," Plenary Symposium, Crop Science Society of America, 82nd Annual Meeting, San Antonio, TX, October 23, 1990.
Brandt, K. G. Invited Testimony before the Subcommittee on Department Operations, Research, and Foreign Agriculture U.S. House of Representatives, on behalf of RICOP, on teaching program authorizations under Title XIV of the 1990 Farm Bill, Washington, DC, February 6, 1990.
Brandt, K. G. “Reaching Students Through the High School Teacher,” American Phytopathological Society Annual Meeting, Richmond, VA, August 23, 1989.
Brandt, K. G.  “A Liberal and Practical Education,” International Science and Education Council National Training Conference, hosted by OICD/USDA, Arlington, VA, March 12-15, 1989.
Brandt, K. G.  “International Perspectives for Undergraduate Students,” 1988 Joint Conference, The Ohio State University, Columbus, OH, December 12-13, 1988.
Brandt, K. G.  “And Where in the World Will You Work?” American Association of State Colleges of Agriculture and Renewable Resources (AASCARR) Annual Meeting, University of Wisconsin - River Falls, River Falls, WI, October 3, 1988.
Brandt, K. G.  “A Blue Guitar: Prescription for Change,” Vocational Agricultural Teachers Summer Workshop, Trafalgar, IN, June 28, 1988.
Brandt, K. G. “Improving the International Dimensions of Teaching and Curriculum” Association of U.S. University Directors of International Agriculture Programs (AUSUDIAP) Annual Meeting, University of Arkansas, Fayetteville, AR, June 9, 1988.
Brandt, K. G. “Xenophobia: A Curricular Disease of Insidious Effect,” Instructional Improvement Workshop, College of Agriculture, University of Missouri, Columbia, MO, May 18, 1988.
Brandt, K. G. Focus on Opportunities Unique to Science -- Panel Discussion Moderator FOCUS 1988 Symposium, National Academy of Sciences, Washington, DC, April 18, 1988.
Brandt, K. G. “Xenophobia: A Curricular Disease of Insidious Effect,” Curriculum Globalization Workshop, College of Agriculture, University of Nebraska, Lincoln, NE, March 31, 1988.
Brandt, K. G. “Does Your Mushroom Soup Have Enough Mushrooms?” Indiana Crop Improvement Association, Annual Meeting, Indianapolis, IN, February 5, 1988.
Brandt, K. G.  “The Impact of Biotechnology on Higher Education in Agriculture,” Eighth Working Conference of Representatives of Higher Education in Agriculture, Organization for Economic Cooperation and Development, Paris, France, November 23-27, 1987.
Brandt, K. G. “Agricultural Curricula -- Some Provocative Questions,” National Curriculum Revitalization Conference, St. Louis, MO, October 21, 1987.
Brandt, K. G. “Criticism and Change: The Need to Respond,” 1986 Annual Extension Conference, Purdue University, October 22, 1986.
Brandt, K. G. “Your Purdue University Agricultural Experiment Station and Cooperative Extension Service,” Legislative Interim Study Committee Hearing, Indiana General Assembly, Indianapolis, IN, July 10, 1986.
Brandt, K. G.  “The Best of Times, the Worst of Times -- or, Hard Times, Hard Decisions,” Indiana Crop Improvement Association, Annual Meeting, Indianapolis, IN, February 6, 1986.
Brandt, K. G.  “Policy Issues Affecting Food and Agricultural Scientific Expertise Development,” Joint Council for Food and Agricultural Sciences, Washington, DC, November 7, 1985.