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Anjali S Iyer-Pascuzzi

Botany and Plant Pathology 

  • Associate Professor
Lilly Hall Room 1-240

Dr. Iyer-Pascuzzi’s research investigates the mechanisms that plant roots use to perceive and respond to the environment. There are two primary areas of research in the lab. The first is focused on understanding the molecular basis of plant resistance to bacterial wilt, caused by Ralstonia solanacearum. Ralstonia is a devastating soil-borne pathogen that first infects root systems. Despite the devastation it causes, little is known regarding the networks that underlie resistance or susceptibility, and root responses to R. solanacearum are unclear. Using both tomato and Arabidopsis, we focus on understanding resistance responses at three levels of root development: root cell types, root developmental stages, and root architecture. Current questions include, what are the spatio-temporal dynamics of pathogen invasion in resistant and susceptible genotypes? How are different root cell types and developmental stages affected by bacterial wilt? What are the gene regulatory networks involved in the response to bacterial wilt within each cell type? We use a combination of cell biology, genetics, and genomics approaches to address these questions. The major goal of this research is to identify novel forms of resistance to bacterial wilt. Our second area of research is centered around the role of Nodule Inception-Like Proteins (NLPs) in root development. NLP proteins are a unique family of transcription factors found in a wide diversity of plant species. We are studying the molecular mechanisms through which these proteins mediate root development and stress responses in Arabidopsis.  

More information is available on the Iyer-Pascuzzi lab page -

Awards & Honors

(2016) New Innovator Award. Foundation for Food and Agriculture Research.

(2016) Kohls Early Career Award. Botany and Plant Pathology.

(2015) Kohls Early Career Award. Botany and Plant Pathology.

Selected Publications

Caldwell, D. L., Kim, B., & Iyer-Pascuzzi, A. (2017). Ralstonia solanacearum differentially colonizes roots of resistant and susceptible tomato plants. Phytopathology, 107, 528-536. doi:10.1094/PHYTO-09-16-0353-R

Balduzzi, M., Binder, B. M., Bucksch, A., Chang, C., Hong, L., Iyer-Pascuzzi, A., . . . Sparks, E. E. (2017). Reshaping plant biology: Qualitative and quantitative descriptors for plant morphology. Frontiers in Plant Science, 8(FEBRUARY). doi:10.3389/fpls.2017.00117

Topp, C., Iyer-Pascuzzi, A., Anderson, J., Lee, C., Zurek, P., Symonova, O., & Et al (2013). 3D Phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture. Proceedings of the National Academy of Science, USA, 110(18), E1695-704.

Karve, R. A., Suarez, F., & Iyer-Pascuzzi, A. (2016). The Transcription Factor NIN-LIKE PROTEIN7 Controls Border-Like Cell Release. Plant Physiology, 171(3), 2101-2111. doi:10.1104/pp.16.00453

Fang, S., Clark, R., Zheng, Y., Iyer-Pascuzzi, A., Weitz, J., Kochian, L., . . . Benfey, P. (2013). Genotypic recognition and spatial responses by rice roots. Proceedings of the National Academy of Science, USA, 110(7), 2670-5.

Eckhardt, E. A., Kim, B., & Iyer-Pascuzzi, A. (2016). Mechanisms of quantitative disease resistance in plants. Seminars in cell & developmental biology, 56, 201-208. doi:10.1016/j.semcdb.2016.05.015

Kim, B. S., French, E., Caldwell, D. L., Harrington, E. J., & Iyer-Pascuzzi, A. (2015). Bacterial wilt disease: Host resistance and pathogen virulence mechanisms. Physiological and Molecular Plant Pathology, 95, 37-43. doi:10.1016/j.pmpp.2016.02.007

Iyer-Pascuzzi, A., Zurek, P., & Benfey, P. (2013). High-throughput, non-invasive imaging of root systems. Methods in Molecular Biology, 959.

Karve, R. A., & Iyer-Pascuzzi, A. (2015). Digging deeper: high-resolution genome-scale data yields new insights into root biology. Current opinion in plant biology, 24, 24-30. doi:10.1016/j.pbi.2015.01.007

Iyer-Pascuzzi, A., & Sozzani, R. (2014). Postembryonic control of root meristem growth and development. Current Opinion in Plant Biology, 17, 12-Jul.

Botany and Plant Pathology, 915 West State Street, West Lafayette, IN 47907 USA, (765) 494-4614

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