Christopher G Oakley

Botany and Plant Pathology

Assistant Professor

Phone

765.494.9644

Fax

765.494.0363

Office

Lilly Hall Room 1329

Email

oakleyc@purdue.edu

Personal Website

The Oakley lab is broadly interested in the ecological and evolutionary genetics of plants. One main focus of our research is the genetic basis of local adaptation. Local genotypes are often found to grow, survive, and/or reproduce better than non-local genotypes, suggesting that adaptation to one environment is costly in other environments (fitness tradeoffs across environments). Despite much empirical study, little is known about the mechanisms and genetic basis of local adaptation. Using locally adapted populations of Arabidopsis thaliana from near the northern and southern edge of the native range, we investigate the genetic basis of local adaptation, adaptive traits (e.g., freezing tolerance), and genetic tradeoffs (fitness tradeoffs attributable to individual loci). We have developed a variety of genetic stocks that we use in field and growth chamber experiments in concert with genetic and genomic approaches.

A second main focus of our research is the consequences of genetic drift for adaptation and population persistence. A number of factors common in natural populations (e.g., a history of population bottlenecks) can increase both the chance loss of beneficial mutations and the chance fixation of deleterious mutations. Heterosis, the increased fitness in crosses between populations relative to fitness within populations, is thought to be due in part to the masking of these fixed deleterious recessive alleles in the heterozygous state. We are investigating the geographic pattern and genetic basis of heterosis in natural populations of A. thaliana to study the balance between selection and genetic drift in nature.

Faculty spotlight:

https://ag.purdue.edu/stories/center-for-plant-biology-faculty-spotlight-chris-oakley/

Awards & Honors

(2015) Anton Lang Memorial Research Excellence Award. Michigan State University.

Selected Publications

Oakley, C. G., Lundemo, S., Agren, J., & Schemske, D. W. (in press). Heterosis is common and inbreeding depression absent in natural populations of Arabidopsis thaliana. Journal of Evolutionary Biology.

Price, N., Moyers, B. T., Lopez, L., Lasky, J. R., Monroe, G., Mullen, J. L., . . . McKay, J. K. (2018). Combining population genomics and fitness QTLs to identify the genetics of local adaptation in Arabidopsis thaliana. Proceedings of the National Academy of Sciences, 115, 5028-5033.

Oakley, C. G., Savage, L., Lotz, S., Larson, R., Thomashow, M. F., Kramer, D. M., & Schemski, D. W. (2018). Genetic basis of photosynthetic responses to low temperature in locally adapted populations of Arabidopsis thaliana. Journal of Experimental Botany, 69, 699-709.

Agren, J., Oakley, C. G., Lundemo, S., & Schemske, D. W. (2017). Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: QTL mapping and estimates of selection. Evolution, 71, 550-564.

Dittmar, E. L., Oakley, C. G., Conner, J. K., Gould, B. A., & Schemske, D. W. (2016). Factors influencing the effect size distribution of adaptive substitutions. Proceedings of the Royal Society B: Biological Sciences, 283(1828). doi:10.1098/rspb.2015.3065

Oakley, C. G., Ågren, J., & Schemske, D. W. (2015). Heterosis and outbreeding depression in crosses between natural populations of Arabidopsis thaliana. Heredity, 115, 73-82.

Oakley, C. G., Ågren, J., Atchison, R. A., & Schemske, D. W. (2014). QTL mapping of freezing tolerance: links to fitness and adaptive trade-offs. Molecular Ecology, 23(17), 4304-15. doi:10.1111/mec.12862

Ågren, J., Oakley, C. G., McKay, J. K., Lovell, J. T., & Schemske, D. W. (2013). Genetic mapping of adaptation reveals fitness trade-offs in Arabidopsis thaliana. Proceedings of the National Academy of Sciences, USA, 110, 21077-21082.