Botany and Plant Pathology Seminar Series
Speaker: Mr. Guotian Li - Department of Botany and Plant Pathology - Purdue University
Topic: Mst50 is involved in mulitple signaling pathways in Magnaporthe oryzae
When: Wednesday, January 23, 2013 at 3:30 pm in WSLR 116

Rice Blast, caused by the ascomycete fungus Magnaporthe oryzae, is one of the most devastating diseases on cultivated rice worldwide, and the annual lose in rice production from Rice Blast is estimated to be enough to feed more than 60 million people. In M. oryzae, multiple signaling pathways are involved in pathogenicity, including the mitogen-activated protein kinase (MAPK) pathways. PMK1 MAPK pathway regulates the appressorium formation and MPS1 MAPK pathway is require for the maintenance of cell wall integrity.  The third MAPK OSM1 pathway is involved in osmotic stress response and essential for fungal survival in natural habitats. My research has focused on Mst50, which previously identified as an adaptor protein in the PMK1 pathway and essential for appressorium formation.  My goal was to better understand the role of Mst50 in the signaling pathways associated cell wall integrity and osmotic stress response. In this study, I used a protein affinity approach to identify components that interacted with Mst50 in vivo. My results indicate that Mst50 regulates the MPS1 cell wall integrity MAPK pathway by interacting with Mck1, the MAPKKK in this pathway. Mst50 is also involved in osmotic regulation by interacting with histidine kinase Hik1 in the MAPK OSM1 pathway. This study illustrates how Mst50 functions as an important adaptor protein across multiple signaling pathways in M. oryzae.

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