A key benefit of MAGIC is that it has the
potential to reveal genetic variation that normally remains hidden or cryptic
and therefore inaccessible to genetic dissection. By having a mutant in the
background, MAGIC serves to hypersensitize the
segregating populations to potential changes in the reporter phenotype, thereby
reducing the background noise and amplifying the effect of the relevant
gene/QTL in the trait of interest. This allows the detection and mapping of genes that have only subtle (though potentially important) effects in wild-type germplasm.