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Kee-Hong Kim

Department of Food Sciences 

  • Associate Professor of Food Science
  • Assistant Professor of Food Science
765.496.2330
NLSN Room 2239
745 Agriculture Mall Drive
West Lafayette, In 47907

Foods and Nutrition 

  • Courtesy Assoc Professor of Food & Nutr
  • Courtesy Assistant Professor

Education
Post-doctoral Fellowship –University of California, Berkeley, CA
Ph.D.–Rutgers University, NJ, 1999
M.S.–Seoul National University, Seoul, Korea
B.S.-Seoul National University, Seoul, Korea

Affiliations
Member, American Society for Nutrition (ASN) 
Member, Institute of Food Technologists (IFT)

Research
Obesity is a global health problem. Obesity contributes to the increased prevalence of other chronic diseases, including type 2 diabetes and coronary heart diseases, which are the leading causes of mortality and morbidity in the U.S. Activation of adipocyte differentiation (adipogenesis) and inflammatory response of adipose tissue has been known to contribute to the development of obesity, and obesity-associated chronic diseases. Despite having continuous attention on dietary phytochemicals as rich therapeutic/preventive sources for many diseases, a few such compounds are known to have anti-obese property. In an effort to develop dietary strategies to prevent the generation of adipose tissue and its associated pathogenesis, we employ molecular and biochemical studies utilizing cultured mammalian cells and animal model of obesity to study the following projects.

  1. Dietary regulation of development of adipose tissue and its function:
    Curcumin has recently been proposed to have anti-cancer and anti-obesity properties. Our lab conducts mechanistic studies on understanding the mechanism of curcumin-regulated adipose development and function. The efficacy of natural form of curcumin and water-soluble curcumin in improving bioavailability and physiological function both in vitro and in vivo has also been studied. We are also interested in elucidating potential anti-obesity function of piceatannol, a metabolite of resveratrol found in red wine, and its cellular target in adipocytes.  
  2. Dietary control of cellular stress signaling pathway and its associated adipose dysfunction:
    A micronutrient selenium exists in various forms with different biological activities. Although selenium is known to exhibit a beneficial function in cancerous cells, its role in metabolically active tissues such as adipose tissue and liver is unknown. Our goal is to elucidate the beneficial function of selenium in adipose development and function. In particular, we are interested in testing the anti-adipogenic function of selenium and its role in selenoprotein-regulated endoplasmic reticulum stress signaling pathway in adipocytes.
  3. Adipose tissue, aging and cellular senescence:
    Adipose tissue dysfunction has been shown to be associated with aging. This includes dysregulated inflammation, tissue remodeling, senescence-like phenotype in preadipocytes and adipocytes. However, the molecular basis underlying aging-induced adipocytes dysfunction is unknown. Furthermore, dietary modulation of cellular senescence in adipocytes has not yet been elucidated. Advanced glycation end-products (AGEs) are generated in the late stage of Maillard reaction during food processing (e.g., frying, roasting or cooking). Both food-driven (exogenous) and biological-driven (endogenous) AGEs are known to play a detrimental role in human health. Evidence suggests that elevated levels of intracellular and extracellular AGEs, and activation of receptors for AGEs (RAGE), collectively termed AGE-RAGE axis, are associated with the development of aging and its-related diseases. In line with this, our group is interested in elucidating the molecular link between aging and adipose dysfunction, and the biological function of AGE-RAGE axis in adipose biology.

Awards & Honors

(2011) Role of Glycated Dietary Proteins in Lipid Dysfunction of Adipose Tissue and Muscle in Aging. Ralph W. and Grace M. Showalter Research Trust Award.

(2009) Anti-Obese Function of Curcumin. Ralph W. and Grace M. Showalter Trust Award.

(2008) 2008 Summer Faculty Grant. Purdue Research Foundation.

(2008) Agricultural Research Program Assistantship. College of Agriculture-Purdue University.

Selected Publications

Chen, C. Y., Martorano, A., Moon, Y. S., & Kim, K. (2012). An advanced glycation end products (AGEs)-the receptor for AGEs axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein function.. Journal of Biological Chemistry, 287, 44498-44507. Retrieved from http://www.jbc.org/content/287/53/44498.abstract?sid=38c2cf98-42e3-440f-85a4-1695806a4867

Kwon, J. Y., Seo, S. G., Heo, Y. S., Yue, S., Cheng, J. X., Lee, K. W., & Kim, K. (2012). Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation.. Journal of Biological Chemistry, 287, 11566-11578. Retrieved from http://www.jbc.org/content/287/14/11566.full?sid=995c5cca-088c-4388-a647-67c97d0bd775

Kwon, J. Y., Seo, S. G., Yue, S., Cheng, J. X., Lee, K. W., & Kim, K. (2012). An inhibitory effect of resveratrol in the mitotic clonal expansion and insulin signaling pathway in the early phase of adipogenesis.. Nutrition Research, 32, 607-616. Retrieved from http://www.nrjournal.com/article/S0271-5317(12)00141-8/abstract

Kim, C. Y., Kim, G. N., Wiacek, J., Chen, C., & Kim, K. (2012). Selenate inhibits adipogenesis through induction of transforming growth factor-β1 (TGF-β1) signaling.. Biochemical and Biophysical Research Communications, 426, 551-557. Retrieved from http://www.sciencedirect.com/science/article/pii/S0006291X12016932

Kim, K., Kim, G. N., & Lee, K. W. (2012). Phytochemicals in Prevention and Treatment of Obesity and Its Related Cancer. In Nutrition in the Prevention and Treatment of Disease (Vol. 3, pp. 391-406).

Kim, C., Le, T., Cheng, J. X., & Kim, K. (2011). Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion.. Journal of Nutritional Biochemistry, 22(10), 910-20. Retrieved from http://www.sciencedirect.com/science/article/pii/S0955286310001920

Kim, K., & Park, Y. (2011). Food components with anti-obesity effect.. Annu Rev Food Sci Technol, 2, 237-57. Retrieved from http://www.annualreviews.org/doi/full/10.1146/annurev-food-022510-133656

Kim, C., Bordenave, N., Ferruzzi, M. G., Safavy, A., & Kim, K. (2011). Modification of curcumin with polyethylene glycol enhances the delivery of curcumin in preadipocytes and its antiadipogenic property.. Journal of Agriculture and Food Chemistry, 59(3), 1012-20. Retrieved from http://pubs.acs.org/doi/abs/10.1021/jf103873k

Jaworski, K., Ahmadian, M., Duncan, R. E., Sarkadi-Nagy, E., Varady, K. A., Hellerstein, M. K., . . . Sul, H. S. (2009). AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nature Medicine, 15(2), 159. Retrieved from http://www.nature.com/nm/journal/v15/n2/full/nm.1904.html

Kim, K. (2009). Perspective in Regulation of Adipogenesis by Bioactive Food Components. Food Science and Industry, 42(4), 51.