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Stephen R Lindemann

Department of Food Sciences 

  • Assistant Professor Food & Nutrition Sci
765.494.9207
Nelson Hall of Food Science (NLSN) Room 3215
745 Agriculture Mall Drive
West Lafayette, IN 47907

Foods and Nutrition 

  • Assistant Professor Food & Nutrition Sci

Dr. Lindemann's research targets ways that diet influences the gut microbiome and the effects of those shifts in that gut colony of microorganisms have on health, such as inflammation and gut colonization by pathogens. The goal is to discover dietary solutions to health problems such as Crohn's disease, diabetes, inflammatory bowel disease, colorectal cancer, ulcerative colitis and more. Specifically, Dr. Lindemann's lab focuses on using molecular ecology techniques to understand how diet influences the composition and stability of the gut microbiome; how gut microbiome metabolism of dietary components influences production and absorption of bioactive microbial metabolites; how metabolic interactions between microbes alter polysaccharide fermentation and nitrogen metabolism in the colon; and how these interactions between beneficial microbes exclude pathogenic organisms and modulate inflammation in the colon. 


Current Graduate Students and Research Lab Members

Selected Publications

Tuncil, Y., Chen, M., Yao, T., & Lindemann, S. R. (2018). Polysaccharide chemical structure controls on fermentation by gut microbiota, metabolic outputs, and interspecies interactions. 255.

Xu, C., Couvillion, S. P., Sontag, R. L., Isern, N. G., Maezato, Y., Lindemann, S. R., . . . Metz, T. O. (n.d.). MetFish: A Metabolomics Platform for Studying Microbial Communities in Chemically Extreme Environments: Supplemental Section. Cold Spring Harbor Laboratory. doi:10.1101/518647

Lindemann, S. R. (2010). Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. Journal of Leukocyte Biology. doi:10.1189/jlb.1209811

Buchan, B. W., McCaffrey, R. L., Lindemann, S. R., Allen, L. H., & Jones, B. D. (2009). Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. Infection and Immunity, 77(6), 2517-2529. doi:10.1128/IAI.00229-09

Schulert, G. S., McCaffrey, R. L., Buchan, B. W., Lindemann, S. R., Hollenback, C., Jones, B. D., & Allen, L. H. (2009). Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. Infection and Immunity, 77(4), 1324-1336. doi:10.1128/IAI.01318-08

Lindemann, S. R., McLendon, M. K., Apicella, M. A., & Jones, B. D. (2007). An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells. Infection and Immunity, 75(6), 3178-3182. doi:10.1128/IAI.01811-06

Xu, C., Couvillion, S. P., Sontag, R. L., Isern, N. G., Maezato, Y., Lindemann, S. R., . . . Metz, T. O. (n.d.). MetFish: A Metabolomics Platform for Studying Microbial Communities in Chemically Extreme Environments: Supplemental Section. Cold Spring Harbor Laboratory. doi:10.1101/518647

Tuncil, Y. E., Thakkar, R. D., Marcia, A. D., Hamaker, B. R., & Lindemann, S. R. (2018). Divergent short-chain fatty acid production and succession of colonic microbiota arise in fermentation of variously-sized wheat bran fractions. Scientific Reports, 8(1). doi:10.1038/s41598-018-34912-8

Tuncil, Y. E., Thakkar, R. D., Arioglu-Tuncil, S., Hamaker, B. R., & Lindemann, S. R. (2018). Fecal Microbiota Responses to Bran Particles Are Specific to Cereal Type and in Vitro Digestion Methods That Mimic Upper Gastrointestinal Tract Passage. Journal of Agricultural and Food Chemistry, 66(47), 12580-12593. doi:10.1021/acs.jafc.8b03469

Rosnow, J. J., Hwang, S., Killinger, B. J., Kim, Y., Moore, R. J., Lindemann, S. R., . . . Wright, A. T. (2018). A cobalamin activity-based probe enables microbial cell growth and finds new cobalamin-protein interactions across domains. Applied and Environmental Microbiology, 84(18). doi:10.1128/AEM.00955-18

Department of Food Science, 745 Agriculture Mall Drive, West Lafayette, IN 47907, (765) 494-8256

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