Profile Image

Joshua R Widhalm

Horticulture and Landscape Architecture 

  • Assistant Professor of Horticulture
Horticulture Room 112
625 Agriculture Mall Dr
West Lafayette, IN 47907

Dr. Joshua Widhalm earned his Ph.D. via the Center for Plant Science Innovation at the University of Nebraska-Lincoln studying plant quinone metabolism.  Then, he did his postdoctoral research with Dr. Natalia Dudareva in the Department of Biochemistry at Purdue University investigating the metabolism of phenylalanine and phenylalanine-derived natural products in plants.  From 2012-2015, Dr. Widhalm was a Life Sciences Research Foundation Fellow sponsored by The Gordon and Betty Moore Foundation.

Dr. Widhalm’s research program is focused on plant allelochemicals, natural products released into the environment that influence the growth and development of other species.  He is particularly interested in elucidating the biosynthesis of allelopathic naphthoquinones and investigating their metabolic connection with quinones involved in respiration and photosynthesis.  His research on allelopathic naphthoquinones will also encompass deciphering the molecular mechanisms involved in their release into the environment, determining their biochemical modes of action, and exploring their roles in promoting (a)biotic stress resistance.  The long term goal of Dr. Widhalm’s research program is to translate the gained basic knowledge into innovative strategies to harness plant allelochemicals for crop improvement.  Dr. Widhalm is also working on identifying new naturally-occurring derivatives of plant naphthoquinones, which have emerged as promising anti-cancer drugs.

Awards & Honors

(2018) Scialog Fellow for Chemical Machinery of the Cell. Research Corporation for Science Advancement and The Gordon and Betty Moore Foundation.

(2017) Bravo Award. Purdue University.

(2015) Don Carlson Outstanding Postdoc Award. Purdue University.

(2012) Life Sciences Research Foundation Fellow. The Gordon and Betty Moore Foundation.

Selected Publications

McCoy, R. M., Utturkar, S. M., Crook, J. W., Thimmapuram, J., & Widhalm, J. R. (2018). The origin and biosynthesis of the naphthalenoid moiety of juglone in black walnut. Horticulture Research, 5, 67. doi:10.1038/s41438-018-0067-5

Widhalm, J. R., & Rhodes, D. (2016). Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants. Horticulture Research, 3, 16046. doi:10.1038/hortres.2016.46

Henry, L. K., Thomas, S. T., Widhalm, J. R., Lynch, J. H., Davis, T. C., Kessler, S. A., . . . Dudareva, N. (2018). Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nature Plants, 4(9), 721-729. doi:10.1038/s41477-018-0220-z

Adebesin, F. O., Widhalm, J. R., Lynch, J. H., McCoy, R. M., & Doudareva, N. (2018). A peroxisomal thioesterase plays auxiliary roles in plant β-oxidative benzoic acid metabolism. The Plant Journal, 93(5), 905-916. doi:10.1111/tpj.13818

Adebesin, F. O., Widhalm, J. R., Boachon, B., Lefèvre, F., Pierman, B., Lynch, J. H., . . . Dudareva, N. (2017). Emission of volatile organic compounds from petunia flowers is facilitated by an ABC transporter. Science (New York, N.Y.), 356(6345), 1386-1388. doi:10.1126/science.aan0826

Widhalm, J. R., Gutensohn, M., Yoo, H., Adebesin, F., Qian, Y., Guo, L., . . . Dudareva, N. (2015). Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network. Nature Communications, 6(8142). doi:10.1039/ncomms9142

Widhalm, J. R., Jaini, R., Morgan, J. A., & Dudareva, N. (2015). Rethinking how volatiles are released from plant cells. Trends in Plant Science, 20(9), 545-550.

Block, A., Widhalm, J. R., Fahiti, A., Cahoon, R. E., Wamboldt, Y., Elowsky, C., . . . Basset, G. J. (2014). The origin and biosynthesis of the benzenoid moiety of ubiquinone (coenzyme Q) in arabidopsis. The Plant Cell, 26(5), 1938-1948.

Widhalm, J. R., Ducluzeau, A. L., Buller, N. E., Elowsky, C. G., Olsen, L. I., & Basset, G. J. (2012). Phylloquinone (Vitamin K1) biosynthesis in plants: two peroxisomal thioesterases of Lactobacillales origin hydrolyze 1,4-dihydroxy-2-naphthoyl-CoA. The Plant Journal.

Widhalm, J. R., Van Oostende, C., Furt, F., & Basset, G. J. (2009). A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1. Proceedings of the National Academy of Sciences USA, 106(14), 5599-55603.

Horticulture & Landscape Architecture, 625 Agriculture Mall Drive, West Lafayette, IN 47907-2010 USA, (765) 494-1300

© Purdue University | An equal access/equal opportunity university | Integrity Statement | Copyright Complaints | Maintained by Agricultural Communication

Trouble with this page? Disability-related accessibility issue? Please contact us at agweb@purdue.edu so we can help.

Sign In