Botany and Plant Pathology Seminar Series
Speaker: Dr. Israel Ausin - Centro Nacional de Biotechnologia, Madrid, Spain - Candidate for Epigenetic and Chromatin Biology Position in Botany and Plant Pathology
Topic: Uncovering New Proteins in the RdDM Pathway
When: Monday, March 25, 2013 at 9:30 pm in WSLR 116

DNA methylation is an epigenetic mark that is associated with the repression of genes and transposable elements. In Arabidopsis, maintenance of DNA methylation is carried out by three methyltransferases: METHYLTRANSFERASE 1 (MET1), CHROMOMETHYLASE 3 (CMT3) and DOMAINS REARRANGED METHYLTRANSFERASE2 (DRM2). However, DRM2 is solely responsible for establishment of DNA methylation—or de novo methylation—. DRM2 is guided by small interfering RNAs, (siRNAs), in a process known as RNA-directed DNA methylation (RdDM).  By a combination of genetic and biochemical  approaches, we have Isolated and characterized several proteins acting with in the RdDM pathway. The role of these new proteins will be discussed.


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