Department of Biochemistry Seminar | Dr. Luca Busino

DR. LUCA BUSINO

ASSISTANT PROFESSOR, DEPARTMENT OF CANCER BIOLOGY,
UNIVERSITY OF PENNSYLVANIA

SEPTEMBER 27, 2022 | VIRTUAL | 3:30-4:30 P.M.

TITLE: RELEVANCE OF THE CULLIN RING UBIQUITIN LIGASES IN DIFFUSE LARGE B-CELL LYMPHOMA.


Abstract:  Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of lymphoma accounting for approximately 32,000 new cases annually and pursues an aggressive course leading to death in up to 40-50% of cases. The pathogenesis of DLBCL remains incompletely understood thereby impacting the ability to target pathogenetically relevant vulnerabilities. Progress in DLBCL research during the past century is inextricably linked to the groundbreaking developments in fundamental biology and biomedical research that empowered discovery of genetic "driver" alterations. As a consequence, precision cancer medicine has attempted to the identification of an oncogenic driver mutation that encodes a therapeutically actionable target in a large subset of patients within a specific cancer type. Genetic drivers confer unique functional capabilities during tumor development by aberrantly activating signaling transduction pathways. Hence, perturbation of the regulatory pathways that are essential for oncogenic activation can influences therapeutic response and deliver its promise.