About Us

Our research consists of evaluating how dietary fiber’s distinct physicochemical properties determine tolerance levels in normal/diverse and dysbiotic gut bacterial environments. Since it is known that patients diagnosed with Ulcerative Colitis (UC) exhibit fiber intolerance symptoms and have an altered gut microbiome, we aim to identify fibers that are well-tolerated by UC patients and that can exert beneficial metabolites, despite dysbiotic conditions.

Inflammation is a normal part of our body’s defense system and is beneficial when we are sick and when our body is fighting against pathogens. Inflammation, although it serves a purpose when we are sick, can also be a negative side effect of a variety of autoimmune diseases such as Ulcerative Colitis and Crohn’s Disease. In the Reddivari lab, we focus on inflammation concerning digestive system disorders and investigate various natural options to alleviate the inflammation caused by these disorders. Currently, research is being performed in the lab on the role anthocyanins, phlobaphenes, and fibers can play in treating gastrointestinal disorders.

Our research focuses on understanding the gut bacterial metabolism of flavonoids and their impact on low-grade inflammatory diseases. Our lab uses microbiota transplantations and germ-free animal models to understand how variations in the gut microbiota influence the bioactivity and bioavailability of flavonoids. Furthermore, we research how flavonoids influence host bacterial composition, metabolism and their inflammation.