Profile Image

Profile Image

 Profile

Andrew D Mesecar

Biochemistry 

  • Head BCHM/Professor BCHM & BioSci/PCCR Deputy Director
765.494.1607
765.494.7897
BCHM Room 121A

 Awards and Honors

Awards & Honors

(1999) American Association of Colleges of Pharmacy New Investigator Award. American Association of Colleges of Pharmacy.

(1984) U. S. Air Force ROTC Four-Year Scholarship. U. S. Air Force ROTC.

 Patents ‭[2]‬

Patents

No patents were found.

 Publications

Selected Publications

Ghosh, A. K., Brindisi, M., Yen, Y. C., Lendy, E. K., Kovela, S., Cárdenas, E. L., . . . Mesecar, A. D. (2019). Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. ChemMedChem. doi:10.1002/cmdc.201800725

Ghosh, A. K., Ghosh, K., Brindisi, M., Lendy, E. K., Yen, Y. C., Kumaragurubaran, N., . . . Mesecar, A. D. (2018). Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorganic & medicinal chemistry letters, 28(15), 2605-2610. doi:10.1016/j.bmcl.2018.06.045

Ghosh, A. K., Brindisi, M., Yen, Y. C., Cárdenas, E. L., Ella-Menye, J. R., Kumaragurubaran, N., . . . Mesecar, A. D. (2017). Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Bioorganic & medicinal chemistry letters, 27(11), 2432-2438. doi:10.1016/j.bmcl.2017.04.011

Ghosh, A. K., Reddy, B. S., Yen, Y. C., Cardenas, E., Rao, K. V., Downs, D., . . . Mesecar, A. D. (2016). Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes. Chemical science, 7, 3117-3122. doi:10.1039/C5SC03718B

Jain, A. D., Potteti, H., Richardson, B. G., Kingsley, L., Luciano, J. P., Ryuzoji, A. F., . . . Moore, T. (2015). Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. European journal of medicinal chemistry, 103, 252-68. doi:10.1016/j.ejmech.2015.08.049

Ghosh, A. K., Brindisi, M., Yen, Y. C., Xu, X., Huang, X., Devasamudram, T., . . . Tang, J. (2015). Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. Bioorganic & medicinal chemistry letters, 25(3), 668-72. doi:10.1016/j.bmcl.2014.11.087

Vickman, R. E., Crist, S. A., Kerian, K., Eberlin, L., Cooks, R. G., Burcham, G. N., . . . Ratliff, T. L. (2016). Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer. Molecular cancer research : MCR, 14(9), 776-86. doi:10.1158/1541-7786.MCR-16-0137

Zhai, X., Go, M. K., O'Donoghue, A. C., Amyes, T. L., Pegan, S. D., Wang, Y., . . . Richard, J. P. (2014). Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry, 53(21), 3486-501. doi:10.1021/bi500458t

Abuhammad, A., Al-Aqtash, R. A., Anson, B. J., Mesecar, A. D., & Taha, M. O. (2017). Computational modeling of the bat HKU4 coronavirus 3CL<sup>pro</sup> inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus. Journal of molecular recognition : JMR, 30(11). doi:10.1002/jmr.2644

Daczkowski, C. M., Dzimianski, J. V., Clasman, J. R., Goodwin, O., Mesecar, A. D., & Pegan, S. D. (2017). Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species. Journal of molecular biology, 429(11), 1661-1683. doi:10.1016/j.jmb.2017.04.011

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