Food science researchers advance science behind gut health and prebiotics

Story by Emma Ea Ambrose

July 7, 2021

When it comes to improving human gut health, approaches and the success of these approaches are based largely on an individual’s gut ecosystem: the bacteria present, its diversity and other factors. Therefore, trying to improve gut health through application of prebiotics or probiotics can have wildly variable results based on gut flora composition.

Bruce Hamaker, director of the Whistler Center for Carbohydrate Research and distinguished professor of food science, and Thaisa Moro Cantu-Jungles, his post-doctorate research associate, recently discovered a way to select prebiotic fibers that have the potential to provide improvement of gut health where everyone would benefit.

Their study, conducted in vitro, showed an increase in butyrate-producing bacteria with a selected fiber using this new approach. Butyrate is a short-chain fatty acid that supports many of the body’s essential functions from regulating the immune system to digestive health. In donors' gut flora where these bacteria were already present (nine out of ten), Cantu-Jungles and Hamaker observed a steady increase in butyrate producing bacteria and butyrate with the introduction of this fiber.

“Here we have targeted bacteria with a specific fiber, which we think is a significant advancement,” Hamaker said. “We’ve learned about these types of bacteria and what they look for in a fiber. The gut has a few trillion bacteria and roughly a thousand different species. But there is an ecological structure in the gut, just like in the wilds. And just like in nature, it’s a very competitive environment, so the high specificity of certain fibers is what helps target a precise part of this ecosystem.”

The results of this research have implications for human health beyond digestion and gut health.

“There is an opportunity to go into the symbiotic industry with this research-that’s where you ally a prebiotic with a probiotic. Usually it’s not very specific when this is done but with our discovery we can be very specific, we can find out which fiber will boost which bacteria, so they can be introduced together,” Cantu-Jungles said. “Beyond this, we can use gut bacteria to enhance human health, and perhaps even fight pathogens present in the gut.”

This research suggests that other highly specific fibers, when introduced, will boost other beneficial bacteria in the gut in a consistent way, which could have far-reaching implications from the treatment of diseases linked to inflammation to colon diseases.

“Over the years, prebiotics and probiotics have been advertised as improving gut health, but the results are usually marginal,” Hamaker said. “Now, with this research, there is a possibility to actually achieve the beneficial effects that have been advertised in nearly everyone and much more.”

The paper that outlines these discoveries is currently available online and forthcoming in volume 11, issue no. 3 of the mBio journal.

Featured Stories

Paul Ebner, head, Purdue Department of Animal Sciences (photo provided by Josh Clark, Purdue Agricultural Communications)

New animal sciences head appointed by Purdue College of Agriculture dean

Paul Ebner, professor of animal sciences, has been named head of Purdue University’s...

Sugar sweet: Making maple syrup

Warm, fluffy buttermilk pancakes. A comfort classic that rouses us from our slumber into the...

Jay Akridge, former Purdue provost and Agriculture dean, announced as 2024 Hovde Award recipient

The Purdue University College of Agriculture presented the 2024 Frederick L. Hovde Award of...

Undergraduate Student Spotlight: Cheyenne Tate

Cheyenne Tate is a senior in animal sciences with a concentration in biosciences.

A collage of the 2024 FNR Alumni/Career Award Recipients. Top row (Left to right): Dr. John Kershaw, BJ Meadows, Dr. Jacob Goheen. Bottom row (L to R): Dr. Ken Kellner, Dr. Joe Robb, Dr. Zackary Delisle

FNR Announces 2024 Six Career Award Recipients

John A. Kershaw Jr. and Betty Jane “BJ” Meadows were selected as Lifetime Achievement...

Purdue, Agricultural Retailers Association, ASU to host management workshop for ag retail leaders

Agricultural retail managers, agronomists and sales professionals will convene at Arizona State...